Myositis and the Anti-synthetase Syndrome: Bedside to Bench...and Back

In this CME, Chester V. Oddis, MD, and Dana Ascherman, MD, discuss the clinical features of the anti-synthetase syndrome, the characteristics of autoimmune interstitial lung disease, and more.

Educational Objectives 

Upon completion of this activity, participants should be able to:

  • Explain the clinical features of the anti-synthetase syndrome.
  • Recognize features characteristic of autoimmune interstitial lung disease.
  • Describe the role of Jo-1 (HRS) in the immunopathogenesis of the anti-synthetase syndrome.
  • Identify key innate and adaptive immune signaling pathways contributing to a murine model of HRS-induced myositis.
  • Implement new therapeutic strategies based on overlap between murine model and human disease.


All individuals in a position to control the content of this education activity have disclosed all financial relationships with any companies whose primary business is producing, marketing, selling, re-selling, or distributing health care products used by or on patients. All of the relevant financial relationships for the individuals listed below have been mitigated.

Dr. Chester V. Oddis receives:

  • Grant/Research Support: Genetech, CSL Behring, Mallinckrodt
  • Consultant: Pfizer, EMD Serono

Dr. Dana Ascherman receives:

  • Grant/Research Support: Mallinckrodt, TEVA, Argenx, Biogen
  • Consultant: PTC Therapeutics, Lundbeck, EMD Serono

Accreditation Statement

In support of improving patient care, the University of Pittsburgh is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

The University of Pittsburgh designates enduring material activity for a maximum of 1.0 AMA PRA Category 1 Credit[s]™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Other health care professionals will receive a certificate of attendance confirming the number of contact hours commensurate with the extent of participation in this activity.

For your credit transcript, please access our website four weeks post-completion at and follow the link to the Credit Transcript page. If you do not provide the last five digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.

Release Date: 2/27/2023 | Last Modified On: 2/27/2023 | Expires: 2/27/2024


February 27, 2023


February 27, 2024

Related Presenters

Chester V. Oddis, MD

Chester V. Oddis, MD

Director, Myositis Center

Full Profile

Dana Ascherman, MD

Dana Ascherman, MD

Professor of Medicine Division Chief Margaret Jane Miller Endowed Professorship for Arthritis Research

Full Profile