LATE: A Newly Identified Etiology of Dementia

Daniel Varon, MD, discusses a neurocognitive disorder called limbic predominant age related TDP-43 encephalopathy (LATE). LATE is commonly observed in subjects over the age of 80 and can have a similar presentation to Alzheimer’s Disease. Dr. Varon reviews the pathologic, epidemiological, and clinical features of the disease.

Educational Objectives

Upon completion of this activity, participants should be able to:

  • Describe the clinical features of LATE
  • Describe the relevance of LATE in older individuals with cognitive dysfunction
  • Describe some of the diagnostic challenges LATE currently presents


No members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships with any companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

Accreditation Statement

In support of improving patient care, the University of Pittsburgh is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

The University of Pittsburgh designates enduring material activity for a maximum of 0.50 AMA PRA Category 1 Credit[s]™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Other health care professionals will receive a certificate of attendance confirming the number of contact hours commensurate with the extent of participation in this activity.

For your credit transcript, please access our website four weeks postcompletion at and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.

Release Date: 2/16/2021 | Last Modified On: 2/28/2023 | Expires: 2/28/2024


February 16, 2021


February 28, 2024

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Daniel Varon, MD

Daniel Varon, MD

Assistant Professor Psychiatry

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