Deprescribing Anticholinergic Medications in Patients with Severe Mental Illness - Part One: Background and an Overview of an Interventional Pilot Program

Dr. Chengappa and Ana Lupu, PharmD, give a joint presentation on Identifying the side effects associated with anticholinergic medications, including peripheral and central effects.

Educational objectives:

Upon completion of this activity, participants should be able to:

  • Define extrapyramidal symptoms and what medications are used to treat them
  • Identify the side effects associated with anticholinergic medications, including peripheral and central effects
  • Describe how reducing anticholinergic medications for EPS can improve clinical outcomes and quality of life in patients on antipsychotics


No members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships with any companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients..

Accreditation Statement:

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of .5 AMA PRA Category 1 Credits™. Each physician should only claim credit commensurate with the extent of their participation in the activity. Other health care professionals are awarded (0.05) continuing education units (CEU) which are equivalent to .5 contact hour.

For your credit transcript, please access our website 4 weeks post-completion at and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.

Release Date: 2/19/2019 | Last Modified On: 3/11/2020 | Expires: 2/21/2023


February 19, 2019


February 21, 2023

Related Presenters

Kadiamada N. Chengappa, MD

Kadiamada N. Chengappa, MD

Professor of Psychiatry, University of Pittsburgh Department of Psychiatry

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Ana M. Lupu, Pharm D

Ana M. Lupu, Pharm D

Clinical Pharmacist, Forbes Pharmacy Western Psychiatric Institute and Clinic of UPMC Adjunct Instructor of Pharmacy and Therapeutics University of Pittsburgh School of Pharmacy

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