In this presentation, Dr. Hassane Zarour and Dr. Robert Ferris each present updates from University of Pittsburgh Cancer Institute (UPCI) Head and Neck Cancer Specialized Program of Research Excellence (SPORE). Dr. Zarour discusses updates from the Melanoma SPORE and Dr. Ferris provides updates and an overview of the investigators and the projects in head and neck cancer.

Educational objectives:

Upon completion of this activity, participants should be able to:

  • Review the 4 themes of the projects comprising UPCI Spore in Melanoma and Skin Cancer
  • Recognize the role of adjuvant therapy in melanoma
  • Recognize limitations of PD-1 monotherapy in melanoma
  • Identify the role of translational research in head and neck cancer
  • Review the progression of oral premalignancy to invasive cancer and strategies for cancer prevention
  • Identify immune escape mechanisms and immune checkpoint immunotherapy

Reading Resources:

  1. PC Tumeh et al. Nature 515, 568-571 (2014)
  2. Gajewski et al, Current Opinion in Immunology, 2013
  3. Ferris RL, Immunology and Immunotherapy of Head and Neck Cancer. J Clinical Oncology 2015
  4. Bauman, JE et al, Cancer Prev Res (Phila). 2016 Jul;9(7):547-57


Dr. Zaour has financial interests with the following entity or entities producing health care goods or services as indicated below:

  • Grant/Research Support: NIH, DOD, Bristol-Myers Squibb and Merck

Dr. Ferris has financial interests with the following any entity or entities producing health care goods or services as indicated below:

  • Grant/Research Support: AstraZeneca/MedImmune, BMS, Merck, VentriRx Pharmaceuticals
  • Other: Advisory Board: Astra-Zeneca/MedImmune, BMS, Lilly, Merck, Pfizer

All presenters disclosure of relevant financial relationships with any entity producing, marketing, re-selling, or distributing health care goods or services, used on, or consumed by, patients is listed above.  No other planners, members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships to disclose.

Accreditation Statement:

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of .75 AMA PRA Category 1 Credits™. Each physician should only claim credit commensurate with the extent of their participation in the activity. Other health care professionals are awarded (0.075) continuing education units (CEU) which are equivalent to .75 contact hour.

For your credit transcript, please access our website 4 weeks post-completion at http://ccehs.upmc.edu and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.

ABIM MOC Part 2 Credit

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to .75 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. 

To receive your ABIM MOC Part 2 credit, you will need to complete the post-test with a pass rate of 100% and provide your date of birth and ABIM number, along with the other required fields.  This information will be shared with the American Board of Internal Medicine using the Accreditation Council for Continuing Medical Education Program and Activity Reporting System.


Release Date: 4/13/2017 | Last Modified On: 4/13/2017 | Expires: 4/13/2020


April 13, 2017


April 13, 2020

Related Presenters

Hassane Zarour, MD

Hassane Zarour, MD

Professor of medicine, University of Pittsburgh School of Medicine, Dermatologist and cancer immunologist, UPMC Hillman Cancer Center

Full Profile

Robert Louis Ferris, MD PhD

Robert Louis Ferris, MD PhD

Director, UPMC Hillman Cancer Center, Hillman Professor of Oncology, Associate Vice-Chancellor for Cancer Research, Co-Director, Tumor Microenvironment Center, Professor of Otolaryngology, Immunology, and Radiation Oncology

Full Profile