The Intestinal Microbiome and Response to Cancer Therapy

Diwakar Davar, MD, discusses the intestinal microbiome.

Educational Objectives 

Upon completion of this activity, participants should be able to: 

  • Explain that the intestinal microbiome is implicated in the development of response to anti-PD-1 immunotherapy
  • Explain that the intestinal microbiome is implicated in the development of immune-related adverse events (irAEs) to anti-PD-1 immunotherapy
  • Describe that the use of antibiotics and proton pump inhibitors adversely affect responses to anti-PD-1 immunotherapy by impacting the microbiome


All individuals in a position to control the content of this education activity have disclosed all financial relationships with any companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. All of the relevant financial relationships for the individuals listed below have been mitigated.

Dr. Davar receives;

  • Grant/research support: Arcus, Checkmate Pharma, CellSight Technologies, Merck, Immunocore, Tesaro/GSK
  • Consultant: Shionogi and Vedanta

Accreditation Statement

In support of improving patient care, the University of Pittsburgh is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

The University of Pittsburgh designates enduring material activity for a maximum of 0.75 AMA PRA Category 1 Credit[s]™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Other health care professionals will receive a certificate of attendance confirming the number of contact hours commensurate with the extent of participation in this activity.

For your credit transcript, please access our website 4 weeks post-completion at and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.

Release Date: 6/15/2021 | Last Modified On: 8/2/2022 | Expires: 7/8/2023


June 15, 2021


July 8, 2023

Related Presenters

Diwakar Davar, MD

Diwakar Davar, MD

Assistant Professor of Medicine, Division of Hematology/Oncology

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